Isotopically Labeled Compounds
Medchemexpress LLC Theophylline-d6 | 117490-39-8 | 99.3% | 1 MG
Theophylline-d6 is the deuterium labeled Theophylline, a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator. Stable heavy isotopes are incorporated into drug molecules as tracers for quantitation during the drug development process, with deuteration potentially affecting pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable isotope-labeled compound
- Used in internal standards for clinical mass spectrometry
- Deuterium (2H, D) stable isotope-labeled inhibitor
- Used in therapeutic drug monitoring (TDM)
Medchemexpress LLC L-Aspartic acid-15N | 3715-16-0 | 134.10 | 50 MG
L-Aspartic acid-15N is the 15N-labeled version of L-Aspartic acid, an amino acid that can penetrate the blood-brain barrier. It is commonly used for preparing prodrugs to target colon and cecal tissues and in the study of inflammatory conditions.
- Used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Intended for research use only
![Revvity Health Sciences Inc Glucose, D-[6-<sup>3</sup>H(N)]-, 5mCi (185MBq)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502812303.jpg-250.jpg)
Revvity Health Sciences Inc Glucose, D-[6-3H(N)]-, 5mCi (185MBq)
Glucose, D-[6-3H(N)]-, 5mCi (185MBq)
Medchemexpress LLC Dxd-d5 (Exatecan-d5 derivative for ADC) | 1599440-33-1 | 98.9% | 498.51 | 1 ML
Dxd-d5 is a deuterium labeled Dxd, which is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC (DS-8201a).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can influence the pharmacokinetic and metabolic profiles of drugs.
- Intended for research use only.
Medchemexpress LLC Creatine-d3 | 143827-19-4 | 99.5% | 134.15 | 25 MG
Creatine-d3 is a deuterium-labeled Creatine. Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, particularly in muscle and brain.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated into drug molecules, primarily as tracers for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Stearic acid-d5 | 211443-83-3 | 5 MG
Stearic acid-d5 is a deuterium labeled stearic acid, which is a long-chain dietary saturated fatty acid found in many animal and vegetable fats and oils. It is used as a tracer for quantitation in drug development, with deuteration potentially affecting pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled stearic acid
- Used as a tracer for quantitation in drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Store powder at -20°C for 3 years, or 4°C for 2 years
- Store in solvent at -80°C for 6 months, or -20°C for 1 month
Medchemexpress LLC Ketoprofen-d3 | 159490-55-8 | 99.4% | 5 MG
Ketoprofen-d3 is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. It is for research use only. This compound can be used as a tracer and as an internal standard for quantitative analysis.
- Deuterium labeled compound
- Non-steroidal anti-inflammatory agent
- Potent inhibitor of COX-1 and COX-2
- Used as a tracer for quantitation during drug development
- Internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-di(methyl-d3)- | 1184986-45-5 | 98.7% | 1 MG
Gemfibrozil-d6 is the deuterium labeled form of Gemfibrozil, a known activator of PPAR-α and a lipid-lowering agent. It also functions as a nonselective inhibitor of several P450 isoforms. This compound is intended for research use only and serves as a valuable tool in scientific investigations, particularly as a tracer or an internal standard for quantitative analysis using techniques like NMR, GC-MS, or LC-MS.
- Deuterium labeled form of gemfibrozil
- Activator of PPAR-α
- Used as a lipid-lowering agent
- Nonselective inhibitor of several P450 isoforms
- Suitable as a tracer in research
- Ideal as an internal standard for quantitative analysis
- Incorporates stable heavy isotopes for pharmacokinetic studies
Cayman Chemical Acephate-d3, Purity: ≥99% deuterated forms (d1-d3), CAS: 2140327-70-2, 1 mg
An internal standard for the quantification of acephate by GC- or LC-MS
Cambridge Isotope Laboratories GUANOSINE 5'-TRIPHOSPHATE (GTP), AMMONIUM SALT (D, 97%+) CHEM PUR. >90% (IN SOLN), 20 UMOL
GUANOSINE 5'-TRIPHOSPHATE (GTP), AMMONIUM SALT (D, 97%+) CHEM PUR. >90% (IN SOLN), 20 UMOL
Medchemexpress LLC Propazine-d14 | 1219802-87-5 | 99.0% | 1 MG
Propazine-d14 is the deuterium labeled Propazine. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled propazine
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis
- Suitable for analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes incorporated into drug molecules for quantitation
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Imipramine-d6 | 65100-45-0 | 1 MG
Imipramine-d6 is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. It shows neuroprotective and immunomodulatory effects and can be used as a tracer or an internal standard for quantitative analysis.
- Fascin1 inhibitor with antitumor activities
- Inhibits serotonin transporter with an IC50 value of 32 nM
- Stimulates U-87MG glioma cells autophagy
- Induces HL-60 cell apoptosis
- Neuroprotective and immunomodulatory effects
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC DL-Alanine-d3 | 53795-94-1 | 100 MG
DL-Alanine-d3 is the deuterium labeled DL-Alanine. It is a racemic compound of L- and D-alanine, used as a reducing and capping agent with silver nitrate aqueous solutions for nanoparticle production. It can also be utilized for researching transition metal chelation, such as Cu(II), Zn(II), and Cd(II). DL-alanine functions as a sweetener, classified with glycine and sodium saccharin, and plays a key role in the glucose-alanine cycle between tissues and the liver.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration may impact the pharmacokinetic and metabolic profiles of drugs.
Cambridge Isotope Laboratories L-LEUCINE (D10, 98%; 15N, 97%), 0.5 G
L-LEUCINE (D10, 98%; 15N, 97%), 0.5 G
Medchemexpress LLC Octanedioic acid-d12 | 169397-99-3 | 98.6% | 186.27 | C8H2D12O4 | 5 MG
Suberic acid-d12 (octanedioic acid-d12) is the deuterium-labeled form of suberic acid (CAS 169397-99-3) supplied as a white to off-white solid for laboratory research. It is intended for use as an isotopically labeled standard or tracer in analytical, metabolic, and mass spectrometry applications and is provided with a certificate of analysis confirming purity and characterization.
- Deuterium-labeled octanedioic acid suitable for tracer and internal standard use.
- CAS 169397-99-3.
- Chemical formula C8H2D12O4; molecular weight 186.27.
- Purity 98.6% as supplied.
- White to off-white solid appearance.
- Supplied in small research pack sizes suitable for analytical applications.
- Intended for research use only, not for human or clinical use.