Isotopically Labeled Compounds
Medchemexpress LLC Theophylline-d6 | 117490-39-8 | 99.3% | 500 UG
Theophylline-d6 is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator. This compound can be used as a tracer and as an internal standard for quantitative analysis.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Hydroxyzine-d4 dihydrochloride | 1219805-91-0 | 98.0% | 5 MG
Hydroxyzine-d4 dihydrochloride is a deuterium labeled form of Hydroxyzine dihydrochloride. This orally active benzodiazepine antihistamine agent functions as a histamine H1-receptor and serotonin antagonist. It possesses anxiolytic effects and is utilized in research for generalized anxiety disorder.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated into drug molecules as tracers for quantitation during drug development.
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC (R)-Lercanidipine-d3 hydrochloride | 1217724-52-1 | 99.9% | 5 MG
(R)-lercanidipine D3 hydrochloride is a deuterium labeled (R)-Lercanidipine hydrochloride. (R)-Lercanidipine-d3 (hydrochloride), the R-enantiomer of Lercanidipine, is a calcium channel blocker. It is for research use only and not sold to patients.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Norethindrone-d6 | 2376036-05-2 | 99.9% | 5 MG
Norethindrone-d6 is the deuterium-labeled version of Norethindrone, a female progestin approved by the FDA for treating endometriosis, uterine bleeding due to abnormal hormone levels, and secondary amenorrhea. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Azide groups.
- Can be used as a tracer and as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Incorporation of stable heavy isotopes like deuterium into drug molecules is primarily for quantitation as tracers during drug development.
- Deuteration can potentially influence the pharmacokinetic and metabolic profiles of drugs.
- Its Alkyne group enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
Medchemexpress LLC Benzyl benzoate-d12 | 352431-26-6 | 99.9% | 5 MG
Benzyl benzoate-d12 is a deuterium-labeled form of Benzyl benzoate, also known as Benzoic acid benzyl ester-d12. It serves as a fragrance ingredient in cosmetic products and is utilized in research for Scabies and Demodex-associated inflammatory skin conditions. It is for research use only and not sold to patients. Deuteration, the incorporation of stable heavy isotopes of hydrogen, carbon, and other elements, is a key feature, offering potential benefits by affecting the pharmacokinetic and metabolic profiles of drugs during development.
- Used as a fragrance ingredient in cosmetic products.
- Utilized in research for Scabies and Demodex-associated inflammatory skin conditions.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration affects the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Fenoterol-d6 (hydrobromide) | 1286129-04-1 | 98.0% | 1 MG
Fenoterol-d6 hydrobromide is the deuterium-labeled version of Fenoterol hydrobromide, a sympathomimetic agent and selective β2-adrenoceptor agonist. It functions as an effective bronchodilator in research contexts, particularly for bronchospasm linked to asthma, bronchitis, and other obstructive airway diseases. This compound is also suitable for use as a tracer and internal standard in quantitative analysis methods such as NMR, GC-MS, or LC-MS.
- Deuterium-labeled version of Fenoterol hydrobromide
- Acts as a selective and orally active β2-adrenoceptor agonist
- Effective bronchodilator for research on bronchospasm associated with respiratory diseases
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Trospium-d8 chloride | 10405-02-4 | 1 MG
Trospium-d8 (chloride) is the deuterium-labeled form of Trospium chloride. Trospium chloride is an orally active, specific, and competitive antagonist of muscarinic cholinergic receptors (mAChRs), exhibiting antimuscarinic activity. It binds with high affinity to muscarinic receptors M1, M2, and M3, but not nicotinic cholinergic receptors.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporation of stable heavy isotopes can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-d7 | 1392208-04-6 | 99.6% | 1 MG
(Rac)-Ropivacaine-d7 is a stable isotope-labeled compound, identified as 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-d7. It appears as a white to off-white solid with an isotopic enrichment of 99.11%. This product is intended for research use only and should be handled by qualified personnel in appropriately equipped facilities.
- High purity of 99.6% (HPLC)
- Stable under recommended storage conditions
- Ideal for laboratory chemical applications and substance manufacturing
- For research use only
Medchemexpress LLC Propranolol-d7 | 98897-23-5 | 98.55% | 1 MG
Deuterium-labeled Propranolol is a nonselective β-adrenergic receptor antagonist, exhibiting high affinity for both β1AR and β2AR. It is utilized in research for various cardiovascular conditions and as a tracer in drug development studies. The incorporation of stable heavy isotopes can influence the pharmacokinetic and metabolic profiles of compounds.
- Nonselective β-adrenergic receptor antagonist with high affinity for β1AR and β2AR.
- Used in the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
- Functions as a tracer and an internal standard for quantitative analysis in techniques like NMR, GC-MS, or LC-MS.
- Deuterium labeling can impact pharmacokinetic and metabolic profiles.
Medchemexpress LLC 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy-2,4,6-d3)methyl]- | 1192812-66-0 | 98.0% | 5 MG
Metaxalone-d3 is a deuterium-labeled derivative of Metaxalone, an FDA-approved muscle relaxant. It primarily acts on the central nervous system by inhibiting polysynaptic reflex arcs. It also inhibits MAO-A, offering anti-inflammatory and antioxidant effects. Stable heavy isotopes have been incorporated into drug molecules for tracing and can influence drug pharmacokinetics and metabolic profiles.
- Deuterium labeled Metaxalone
- FDA-approved muscle relaxant
- Inhibits polysynaptic reflex arcs
- Inhibits MAO-A, providing anti-inflammatory and antioxidant effects
- Isotopic enrichment of 99.10%
Medchemexpress LLC Benzyl alcohol-d1 (Benzenemethanol-d1) | 14915-25-4 | 95.7% | 100 MG
Benzyl alcohol-d1 is a deuterium-labeled benzyl alcohol. It serves as a tracer and internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs
- Stable heavy isotopes like deuterium are incorporated into drug molecules for quantitation during drug development
Medchemexpress LLC Spironolactone-d7 | 99.96% | 100 UG
Spironolactone-d7 is the deuterium labeled version of Spironolactone, an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM and a potent antagonist of androgen receptor with an IC50 of 77 nM. It is known to promote autophagy in podocytes and is commonly used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled compound for accurate tracing
- Can be used as an internal standard in quantitative analysis
- High purity (99.96%) for reliable results
- Supports research in drug development and metabolism
- Applicable in studies related to cancer and endocrine diseases
Medchemexpress LLC Mefenamic Acid-d3 | 1189707-81-0 | 2.5 MG
Mefenamic Acid-d3 is the deuterium labeled Mefenamic acid. Mefenamic acid is a BBB-permeable non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM, respectively. It can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled mefenamic acid
- BBB-permeable non-steroidal anti-inflammatory agent
- Acts as a competitive inhibitor of hCOX-1 and hCOX-2
- Suitable as a tracer for research
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Cortodoxone-d7 (11-deoxycortisol-d7) | 152-58-9 | MFCD00003662 | 353.5 g/mol | C21H23D7O4 | 1 MG
Cortodoxone-d7 is the deuterium-labeled (d7) isotopologue of cortodoxone (11-deoxycortisol) supplied as a purified analytical standard for research use. It is intended for use as a stable isotope internal standard in quantitative mass spectrometry and isotope-dilution assays, enabling accurate analyte quantitation and compensation for matrix effects. Molecular formula C21H23D7O4; molecular weight 353.5 g/mol.
- Deuterium-labeled analog of 11-deoxycortisol for use as an internal standard.
- Suitable for LC-MS/MS and isotope-dilution quantitation workflows.
- Matches chromatographic behavior and ionization of the unlabeled analyte.
- Molecular formula C21H23D7O4; molecular weight 353.5 g/mol.
- Provided as a purified reference standard for analytical and research use.
Medchemexpress LLC Ropivacaine-d7 | 684647-62-9 | 99.7% | 5 MG
Ropivacaine-d7 is deuterium labeled Ropivacaine. Ropivacaine is a potent sodium channel blocker, which blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers. It is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of neuropathic pain management. It can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled Ropivacaine
- Potent sodium channel blocker
- Inhibits impulse conduction by reversibly inhibiting sodium ion influx
- Inhibitor of K2P (two-pore domain potassium channel) TREK-1
- Used for research in neuropathic pain management
- Can be used as a tracer or internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Related to isotope-labeled compounds
- Useful for therapeutic drug monitoring